Studies in patients with asymptomatic hyperuricemia have shown that increased serum urate concentrations are associated with inflammatory responses, including increased IL-6, IL-1β, TNF-α, and IL-18 levels and decreased IL-1Ra and IL-10 levels (Crisan et al., 2016; Crişan et al., 2017). The gene discussed is IL18; the disease is hyperuricemia.