More importantly, Takahashi et al. assessed the role of EV signaling in tumor cell responses to TGF-β and also recognized specific EV-lncRNA mediators, such as linc-ROR, involved in the regulation of the chemotherapy response to chemotherapy (Takahashi et al., 2014; Spinelli et al., 2018). This evidence concerns the gene TGFB1 and neoplasm.