It has been found that EGFR pathway, working collaboratively with the PI3K/PTEN/AKT/mTORC1 pathway, play prominent roles in the development of breast cancer (Davis et al., 2014), prognosis and survival of breast cancer patients (Witton et al., 2003), which means the inhibition of EGFR signaling by the peptides could suppress malignant transformation and build up apoptosis. Here, PTEN is linked to breast cancer.