LDHB is largely used by cancer cells to bypass oxidative phosphorylation process to produce lactate directly from pyruvate to promote the cell proliferation (Vander Heiden et al., 2009; Dennison et al., 2013), while transactivated by the key tumorigenic driver, signal transducer and activator of transcription 3 (STAT3) (Zha et al., 2011). This evidence concerns the gene STAT3 and cancer.