Since secreted LAMC2 promotes the proliferation and survival of cancer cells (Garg et al., 2014; Sato et al., 2014), and excessive fibroblast proliferation and insufficient apoptosis play an important role in keloid pathogenesis (Funayama et al., 2003), we speculated that LAMC2-overexpressing VECs could secrete LAMC2 and thereby promote local fibroblast proliferation and survival. This evidence concerns the gene LAMC2 and cancer.