SERPINA3 and keloid: To assess whether SERPINA3 and LAMC2 could participate in keloid pathogenesis, we asked whether activation with LPS changes the SERPINA3 and LAMC2 expression exposed to it, blood vessels exhibit hyperpermeability, and VECs adopt proinflammatory leukocyte-recruiting phenotypes, including the production of proinflammatory cytokines, chemokines, and adhesion molecules (Wang L. et al., 2017; Dayang et al., 2019).