CGAS and Aicardi-Goutieres syndrome: In autosomal recessive genetic disease, such as Fanconi anemia caused by SLX4FANCP deficiency and Aicardi–Goutieres syndrome (AGS) of three-prime repair exonuclease 1 mutations, LINE-1 expression was upregulated and pro-inflammatory cytokines were produced through the cGAS–STING pathway (Brégnard et al., 2016; Suarez et al., 2018).