CD155 and CD112 molecules are widely expressed in a variety of tissue cells, such as nerve cells, endothelial cells, epithelial cells, antigen-presenting cells, fibroblasts, pathogen infected cells, and a variety of tumor cells (Bottino et al., 2003; Tahara-Hanaoka et al., 2004; Dardalhon et al., 2005; Bryceson et al., 2006; Pende et al., 2006; Gilfillan et al., 2008; Kraus et al., 2016). The gene discussed is PVR; the disease is neoplasm.