Additionally, hyperinsulinemia driven by pancreatic hypersecretion and/or impairments in hepatic insulin clearance could explain changes in glomerular filtration rates and increased renal gluconeogenesis, which in turn causes fatty liver deposition and, as a direct consequence, may lead to dysglycemia (Bril et al., 2014; Naderpoor et al., 2017; Jung et al., 2018; Bergman et al., 2019). This evidence concerns the gene INS and hyperinsulinism.