Nonetheless, Ago-shRNAs have been successfully implemented to knock down the human immunodeficiency virus 1 (HIV-1) RNA and the CCR5 co-receptor for HIV-1 infection (Herrera-Carrillo and Berkhout, 2017b; Herrera-Carrillo et al., 2017b), suggesting a promising future for Ago-shRNA therapeutics. Here, FBXW7 is linked to HIV-1 infection.