Interestingly, the relationship between MITF and stiffness have been established in a recent study that showed that collagen stiffness induces melanoma differentiation through a YAP/PAX3/MITF axis, revealing a distinct lineage-specific route of YAP signaling that contributes to the regulation of melanoma progression (Miskolczi et al., 2018). The gene discussed is PAX3; the disease is melanoma.