BRAF and melanoma: For example, high levels of MITF have been reported to block proliferation (Carreira et al., 2005; Loercher et al., 2005) and its suppression improves the sensitivity of melanoma cells to a BRAF inhibitor (Aida et al., 2017), while in contrast a low MITF level promotes invasion (Carreira et al., 2006) and early resistance (Müller et al., 2014; Pathria et al., 2016).