ABHD11, the mammalian homolog to KmYME (Additional File 2: Supplementary Figures S6, S8), has high expression in metabolically active tissues and is related to many diseases such as Williams-Beuren syndrome (Merla et al., 2002) and lung adenocarcinoma (Wiedl et al., 2011), though the causal connection of ABHD11 to these diseases is not clear. This evidence concerns the gene ABHD11 and Williams syndrome.