ACHE and early-onset autosomal dominant Alzheimer disease: Also, IMERs have been applied for the immobilization of other enzymes involved in other pathologies such as arginase in cardiovascular diseases (André et al., 2011), acetylcholinesterase (AChE) in the treatment of Alzheimer disease (De Simone et al., 2019) or in metabolism studies using the cytochrome P450 enzyme (Nicoli et al., 2008).