TBK1.DF_DN (Barbie et al., 2009) is a gene set composed of genes down-regulated as a combination of an over-expressed oncogenic form of KRAS and the suppression of TBK1, a kinase that regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity (Helgason et al., 2013; Durand et al., 2018). The gene discussed is TBK1; the disease is neoplasm.