By inspired the previously reported anticancer compounds of a series of 4-aryl-4H-chromene (Knox et al., 2007), Carr et al. (2020) synthesized a series of new compounds by the addition of basic aryl ethers at the C-4 position and C-3 modified ester substitution in the benzopyran ring and tested their desired effectiveness against estrogen receptor (ER) as antagonists in MCF-7 tumor cell line (Carr et al., 2020). This evidence concerns the gene ESR1 and neoplasm.