Now, the TF antigen is accessible and, among other interactors, extracellular hGal-3, also overexpressed in various tumor lines, is capable of recognizing and binding to it, so mediating the adhesion of tumor cells to the endothelium leading to metastasis progression (Jeschke et al., 2006; Fortuna-Costa et al., 2014; Mori et al., 2015). The gene discussed is TF; the disease is neoplasm.