In a previous study, we found that crude polyporus polysaccharide could suppress the growth of tumor cells via the TLR4/NF-κB pathway (Zeng et al., 2011) and greatly induce the transformation of M2 subtype macrophages to the M1 subtype in vitro (Jiang et al., 2015). This evidence concerns the gene TLR4 and neoplasm.