In a previous study, we found that crude polyporus polysaccharide could suppress the growth of tumor cells via the TLR4/NF-κB pathway (Zeng et al., 2011) and greatly induce the transformation of M2 subtype macrophages to the M1 subtype in vitro (Jiang et al., 2015). The gene discussed is NFKB1; the disease is neoplasm.