The univariate analysis revealed that age (p = 0.001), Male/Female (p = 0.021), WBC (p = 0.001), NLR (p = 0.000), PCT (p = 0.000), CRP (p = 0.000), LDH (p = 0.000), PaO2/FiO2 (p = 0.000), Serum calcium (p = 0.307), cTnI (p = 0.000), BNP (p = 0.000), CURB-65 (p = 0.000), IL-2R (p = 0.000), IL-6 (p = 0.000), IL-8 (p = 0.043), IL-10 (p = 0.001), TNF-α (p = 0.01), D-dimer (p = 0.003), and Hypertension (p = 0.008) were significant prognostic factors. This evidence concerns the gene TNF and Hypertension.