While Pseudomonas ineffectually utilizes mucins as a carbon source on its own (Flynn et al., 2016), we determined that mucin fermentation by MDMs can stimulate the growth of P. aeruginosa. Moreover, we revealed that SCFAs were also abundant and available in CRS patients with and without P. aeruginosa. Together, these results suggest that the high levels of utilizable metabolites present in sinus mucus may be derived from bacterial mucin degradation by anaerobes in the sinus cavity, which may contribute to the establishment and progression of recalcitrant CRS (Cho et al., 2020). Here, MUC5AC is linked to congenital rubella syndrome.