We observed a similar loss of SAMHD1 and a similar effect of MLN4924 during infection of Toledo and JHC strains, suggesting that this SAMHD1 regulation is well-conserved among HCMV strains, and that the UL/b′ region, which is absent in the Towne strain, is not required for this regulation (Figures 3B,C). The gene discussed is SAMHD1; the disease is infection.