Interestingly, CMV infection enhanced the production of pro-inflammatory cytokines in response to TLR stimulation and indeed increased levels of some soluble mediators were observed by stimulation of blood cells obtained from mononucleosis patients with ligands mimicking both bacterial (TLR2 ligands) and viral (TLR2 and TLR7/8 ligands) products. This evidence concerns the gene TLR7 and infectious mononucleosis.