In this study, we investigated whether CMV mononucleosis was associated with improper TLR functional responses and/or to the presence of SNPs within TLRs selected for their possible functional effects (TLR2 Arg753Gln; TLR3 Pro554Ser; TLR4 Asp299Gly; TLR7 Gln11Leu, and TLR9−1237 T/C). Here, TLR7 is linked to infectious mononucleosis.