US28 expression during latent-infection of CD34+ HPCs plays a key role in the maintenance of latency (Vomaske et al., 2009a; Poole et al., 2013; Crawford et al., 2015, 2019; Cheng et al., 2017; Krishna et al., 2019). The gene discussed is CD34; the disease is disease arising from reactivation of latent virus.