CD34 and disease arising from reactivation of latent virus: In fibroblasts and endothelial/epithelial cells viral particles are produced via a lytic replication cycle, but in CD34+ hematopoietic stem cells (HPCs), the virus establishes a latent infection (Sinzger et al., 2008; Goodrum, 2016; Collins-McMillen et al., 2018a).