Infected monocytes are a vector for viral spread due to their mobility and ability to migrate into most organ tissues (Sinzger and Jahn, 1996; Smith et al., 2004a), and it is the infiltration of infected monocytes into the bone marrow that is required for the establishment of latent infection in the CD34+ HPC reservoir (Streblow and Nelson, 2003; Wills et al., 2015; Collins-McMillen et al., 2018a). The gene discussed is CD34; the disease is disease arising from reactivation of latent virus.