Overall, AT adjacent to malignant breast tumors displays down-regulation of the expression of adipogenesis-related genes Homeobox C Cluster (HOXC) 8, HOXC9, fatty acid binding protein 4 (FABP4) and hormone sensitive lipase (HSL) and up-regulation of inflammatory cytokines, like TNF-α and monocyte chemoattractant protein 1 (MCP-1) and of leptin, with a decrease of adiponectin levels (33). This evidence concerns the gene LEP and breast cancer.