Finally, MSCs isolated from BC patients with pathological stage III disease, induce up-regulation of mRNA expression levels of IL-4, TGF-β1, IL-10, CCR4 and CD25 in peripheral blood leukocytes and an increase of the percentage of CD4 + CD25(high)Foxp3(+) T regulatory cells in vitro, thus sustaining an anti-inflammatory response within the tumor microenvironment (68). Here, TGFB1 is linked to neoplasm.