IRS1 and breast cancer: This is consistent with the finding that in co-coltures of adipocytes- BC cells there is an increase of the exosomal miRNA-144 that promotes beige/brown adipocyte differentiation by downregulating MAP3K8/ERK1/2/PPARγ and of exosomal miRNA-126 that plays a crucial role in metabolic reprogramming of adipocytes, targeting IRS1 (Insulin receptor substrate 1) and AMPK (5’ AMP-activated protein kinase) (41).