BM-MSC homing in BC is mediated by tumor (and CAA) –derived chemokines (MCP-1, CCL5, CXCL 16- chemokine [C-X-C motif] ligand 16, SDF1-stromal cell-derived factor 1), growth factors (VEGF, IGF1, TGFβ, FGF) and miRNAs (i.e., miRNA-126/miRNA-126∗) (49, 50). Here, IGF1 is linked to breast cancer.