Chang et al. have reported that ATSP-7041 directly binds to both MDM2 and MDMX with high affinities (Ki = 0.9 and 7 nM, respectively) and effectively disrupts the p53-MDM2/MDMX bindings, thereby activating p53 signaling in p53 wild-type cancer cells. This evidence concerns the gene MDM2 and cancer.