As shown in Tables 2, 3, univariate Cox proportional hazard regression analysis confirmed high histological grade, high T stage, low ER and PR, HER2 high-expression, late TNM stage, lymph node metastases and high expression of CYP2U1 were significant relevance in 5-DFS and 5-OS for breast cancer patients. This evidence concerns the gene ESR1 and breast carcinoma.