Given that the xenograft tumors developed after the implantation of GBM cells (U87) only without ECs, the formation of such microvessels might imply that loss of PDCD10 in GBM cells facilitates vascular mimicry by triggering a transformation of GBM cells to endothelial phenotype and stimulating tumor-angiogenesis. The gene discussed is PDCD10; the disease is glioblastoma.