In the functional enrichment analysis, HIF-1_H had many subtype-specific pathways, including apoptosis, TNF signaling pathway, PI3K-Akt signaling pathway, prostate cancer Th1 and Th2 cell differentiation, Leukocyte trans-endothelial migration, B cell receptor signaling pathway, and T cell receptor signaling pathway. This evidence concerns the gene AKT1 and Familial prostate cancer.