Hypoxia and overexpression of HIF-1 may be related to radiotherapy and chemotherapy resistance, increased risk of tumor invasion and metastasis, and poor clinical prognosis of most solid tumors, especially PCa (8); therefore, the HIF_1 pathway is considered as a viable pharmacological target in the treatment of solid tumors (9, 10). The gene discussed is HIF1A; the disease is neoplasm.