HIC1 and breast cancer: Previous studies have reported that miR-27b-3p can suppress multiple target genes, such as NISCH (Nischarin protein) (8), ST-14 (suppression of tumorigenicity 14) (9), HIC1 (hypermethylated in cancer 1) (10), PSAP (prosaposin) (11), and PDHX (pyruvate dehydrogenase protein X) (12), to promote tumor progression and metastasis in breast cancer.