Previous studies have reported that miR-27b-3p can suppress multiple target genes, such as NISCH (Nischarin protein) (8), ST-14 (suppression of tumorigenicity 14) (9), HIC1 (hypermethylated in cancer 1) (10), PSAP (prosaposin) (11), and PDHX (pyruvate dehydrogenase protein X) (12), to promote tumor progression and metastasis in breast cancer. The gene discussed is PSAP; the disease is breast cancer.