The authors analyzed the TCR repertoire of TILs in CD8+, CD8–, CD8+PD-1–, or CD8+PD-1+ subsets, respectively, and found that many of the most frequently occurring TCR clonotypes present in the CD8+PD-1+ TIL subset recognized the autologous tumor and tumor antigens, included neoantigens. The gene discussed is PDCD1; the disease is neoplasm.