Reportedly, VEGF can inhibit the innate immune system via hampering the transcriptional program required for maturation of DCs, the critical cells in immune activation, and increasing the presence of MDSCs, which represent a heterogeneous population of cells that accumulate in tumor-bearing hosts, characteristic by their potent immune-suppressive activity against cytotoxic tumor-infiltrating lymphocytes (TIL) (42–45). This evidence concerns the gene VEGFA and neoplasm.