In our previous work, we demonstrated that two variants in BRCA1 (c.2037delinsCC and c.3331_3334del) and one in BRCA2 (c.156_157insAlu) together represent about 50% of all deleterious variants found in Portuguese hereditary breast and ovarian cancer families mostly originated from northern Portugal (13). The gene discussed is BRCA1; the disease is ovarian carcinoma.