P28 inhibits angiogenesis and tumor growth even in p53 null tumors by (i) by preventing angiogenesis via decreasing or inhibiting the activity and phosphorylation of VEGFR-2 tyrosine kinase; (ii) inhibiting FAK, AKT, and PI3K phosphorylation; and (iii) inhibiting the effects of bFGF (FGFR-1) on growth. This evidence concerns the gene PTK2 and neoplasm.