TP53 and cancer: Recently, p28 in combination, sequentially or concurrently, with either DNA-damaging drugs (e.g., doxorubicin, dacarbazine, temozolomide) or anti-mitotic drugs (paclitaxel and docetaxel) was shown to improve the cytotoxic activity of these drugs in a variety of human cancer cells expressing wild-type or mutated p53 and does so at lower concentrations of these agents.