The exposure of p53-mutated (p53mut) DU145 prostate cancer cells to increasing doses and times (h) of p28 showed that DU-145 cells respond to p28 with a decrease in cell proliferation, an increase in intracellular levels of p53 and p21, and no change in the ubiquitin ligase COP1. Here, TP53 is linked to Familial prostate cancer.