CD4 and cancer: Specifically, the proportions of B cells (p = 0.002), cancer-associated fibroblasts (CAFs, p = 1.2e-08), CD4+ T cells (p = 0.003), endothelial cells (p = 2.9e-04), and macrophages (p = 2.0e-12) were significantly higher in the high immune score group compared with the low immune score group, while the proportions of CD8+ T cells were significantly lower (Figure 2E; p = 0.024).