Hence, in the context of cancer, defects in LAP have paradoxically beneficial effects including the activation of tumor infiltrating lymphocytes (TIL), enhanced effector T cells activity and elevated secretion of inflammatory mediators including stimulator of interferon genes (STING), type I interferons (IFNs) and tumor necrosis factor alpha (TNF-α) (13). Here, TGFB1 is linked to neoplasm.