For example, (1) markers of tolerance and the polarization of macrophages to M2 phenotype is observed in LAP-sufficient tumor animal models (13, 76–78), (2) the M2 phenotype correlates with poor prognosis and promotes tumor progression (2, 79), and (3) LAP-sufficiency in tumor mouse models has been shown to accumulate M2 macrophages that support the pro-tumorigenic effects of TAMs (13). This evidence concerns the gene TGFB1 and neoplasm.