HAVCR2 and neoplasm: Moreover, TIM-3 was shown to be connected with lymph node metastasis (N+ vs. N-, OR = 1.59, 95% CI = 1.10-2.29, <i>P</i> = 0.013), tumor grade (G2-3 vs. G1, OR = 1.68, 95% CI = 1.21-2.34, <i>P</i> = 0.002), as well as PD-1 expression (PD-1<sup>high</sup> vs. PD-1<sup>low</sup>, OR = 3.26, 95% CI = 2.20-4.82, <i>P</i> < 0.001).