TNF and cancer: Our data showed that differentially expressed mRNAs were significantly enriched in top 20 KEGG signaling pathways, including Aldosterone-regulated sodium reabsorption, Circadian rhythm, Mismatch repair, Drug metabolism-other enzymes, TNF signaling pathway, Transcriptional misregulation in cancers, TGF-beta signaling pathway, PI3K-Akt signaling pathway and so on (Figure 5B).