Using complementary methodological approaches (i.e. FISH, RNA-Seq, Sanger sequencing), Sharma et al. has recently identified STAT3-JAK2 fusion genes in four of five CD4+ GI T-LPD cases but not in CD8+ or CD4+/CD8+ cases evaluated (16). This evidence concerns the gene STAT3 and disseminated peritoneal leiomyomatosis.