To address whether activating mutations of STAT3 previously reported in lymphomas derived from gamma delta T or NK cells (18) are present also in indolent GI T-LPD cases, Perry et al. screened six mutational hotspots in the SH2 domain of STAT3 in five indolent GI T-LPD case, which did not reveal any activating STAT3 mutation (2). Here, STAT3 is linked to lymphoma.