By screening activating mutations located in the SH2 (Src Homology 2) domain of STAT3, it may be possible differentiate indolent GI T-LPD cases from EATL cases as the former did not have STAT3 mutations (2); whereas EATL cases harbor STAT3 mutations (13). Here, STAT3 is linked to enteropathy-associated T-cell lymphoma.