The observed discrepancy related to STAT3 activation status may be due to relatively lower sensitivity of immunohistochemistry compared to that of western blot, high level of expression of phosphatases that dephosphorylate STAT3, or the intracellular amount of available STAT3 protein in indolent GI T-LPD cells. This evidence concerns the gene STAT3 and disseminated peritoneal leiomyomatosis.