TERT and thyroid tumor: In addition, minimally invasive approaches to detect TERT promoter mutations could be performed in head and neck samples in order to evaluate the feasibility of this marker, and since oral cavity is the most affected site, saliva could possibly be a good source, taking into consideration previous data in other tumors: FNA (Fine-Needle Aspiration) in thyroid tumors (51–53) and cell-free DNA (cfDNA) from urine in urothelial tumors (54–56), which were able to detect the mutation in fluids.