CD40LG and neoplasm: Examples are CAR T-cells that constitutively express the immune-stimulatory CD40 ligand to prevent antigen loss and induce an endogenous anti-tumor immune response (148) or CAR T-cells that secrete a PD-1 blocking scFv and thus increase anti-tumor efficacy of both, CAR T-cells and tumor-specific bystander T-cells (149).