However, FL cell line Karpas 422, carrying EZH2Y641N mutation exhibited slightly higher levels of EZH2, H3K27me3, SUZ12, and EED than the FL cell line DOHH2 carrying EZH2WT, and had PRC2 components comparable to that of MCL cell lines (Figure 1A). Here, EZH2 is linked to mantle cell lymphoma.