Interestingly, although GSK343 rendered more prominent anti-proliferative effects in FL cells than in MCL cells, there was no significant difference in anti-proliferative activity of GSK343 among FL cell lines, DOHH2EZH2WT vs. Karpas 422EZH2/Y641N (Figure 4D) indicating an inherent hypersensitivity to EZH2 inhibitors in FL cells that is unrelated to EZH2 mutation. Here, EZH2 is linked to mantle cell lymphoma.