Based on the AKT pathway, tumors were categorized as: CTLA-4H/H−AKT (N = 156), which do not express membrane CTLA-4, and CTLA-4H/L−AKT, representing our study phenotype where CTLA-4 is up-regulated in tumor cells and is activated-like, as defined by the down-modulation of the AKT pathway. Here, CTLA4 is linked to neoplasm.