By contrast, another 3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine (18F-FDOPA) imaging study in a total of 43 newly diagnosed glioma cases described paradoxically higher 18F-FDOPA uptake in diffuse grade II and III gliomas with IDH mutation (30). The gene discussed is IDH1; the disease is central nervous system cancer.