IDH1 and glioma: One O-(2-18F-fluoroethyl)-L-tyrosine(18F-FET) PET research in a mixed group of glioma patients, which included 16 oligodendrogliomas (IDH mutated and 1p/19q co-deleted), 27 astrocytomas (IDH mutated only) and 47 glioblastomas (IDH-wildtype), suggested that gliomas with IDH mutation are typically shown with a lower tumor to brain ratios(TNRmean and TNRmax), prolonged time to peak, and a slow-rise time-activity curve of 20–50 min (29).