As expected, our data demonstrated that TNRs and SUVSD were significantly lower in the IDH-mutant group compared with those IDH-wildtypes, which are consistent with those of Kim et al. (15) 11C-MET PET derived SUVSD showed the most excellent ability to identify whether glioma had an IDH mutation or not besides other MET PET metrics. Here, IDH1 is linked to central nervous system cancer.