Furthermore, we observed higher levels of immune signatures, including cytolytic activity, IFN-γ signature, immunocostimulator, immunoinhibitor, chemokine, adhesion molecule, MHC I, MHC II, and non-class MHC, in hot HCC immunograms (P < 0.05, Figure 4). The gene discussed is IFNG; the disease is hepatocellular carcinoma.