CUBN and cancer: Referring to a previous study, the steps of the cancer-immunity cycle are characterized by the following eight axes of the IGS: IGS1, T cell immunity; IGS2, tumor neoantigen burden; IGS3, priming and activation; IGS4, trafficking and infiltration; IGS5, recognition of tumor cells; IGS6, inhibitor cells; IGS7, checkpoint expression; and IGS8, inhibitor molecules.