Both de novo synthesized and exogenous FA play important roles in carcinogenesis (28, 39), To extend our findings that FASN inhibition upregulates the expression of CD36 and to further test whether inhibition of CD36 can improve the efficacy of TVB-3664, primary CRC cells from Pt 93 and Pt 130 were treated with CD36 inhibitor SSO and FASN inhibitor TVB-3664, alone or in combination, in both normal and serum-starved media. Here, CD36 is linked to colorectal carcinoma.