Moreover, our in vivo experiments demonstrated that DLX6-AS1 enhanced the expression of MMP-9, uPAR, and cathepsin B. Likewise, reduction of MMP-9, uPAR, and cathepsin B repressed invasion and migration ability in a previous study of PC3 and DU145 prostate cancer cell lines (18). The gene discussed is MMP9; the disease is Familial prostate cancer.