Furthermore, DNA methyltransferase 1 (DNMT1) has extensive expression in gastric (8), colon (9), lung (10), laryngeal (11) cancer cells; and downregulated DLX6-AS1 re-differentiates liver cancer stem cells through promotion of CADM1 by suppressing the methylation of the CADM1 promoter (12). This evidence concerns the gene DNMT1 and cancer.