To confirm our observations of the effect of YTHDC2 on radiosensitivity, an NPC xenograft mouse model was established by using a subcutaneous injection of CNE2-IRR cells infected with YTHDC2 shCON, shYTHDC2-1, and shYTHDC2-3 lentivirus, respectively. This evidence concerns the gene YTHDC2 and nasopharyngeal carcinoma.