Using the same iPSC markers, we have also shown the presence of two CSC subpopulations within head and neck metastatic malignant melanoma (HNmMM): an OCT4+/SOX2+/KLF4+/c-MYC+ CSC subpopulation within the TNs, and another in the PTS with NANOG present only in two of the 20 cases studied (44). This evidence concerns the gene SOX2 and metastatic melanoma.