SOX2 and cancer: The low expression of SOX2 within mHNcSCC-derived primary cell lines and the lower proportions of SOX2 positive cells in mHNcSCC tissue samples on IHC staining and ISH staining compared to the other four iPSC markers may reflect the aggressiveness of this cancer, as decreased SOX2 expression has been associated with carcinogenesis and the development of OCSCC (60).