For instance, Zinc-finger E-box binding homeobox 1, ZEB1 (also known as δEF1), and zinc finger E-box-binding homeobox 2, ZEB2 (also known as SIP1), the upregulation of which facilitate EMT and tumor metastasis by downregulating E-cadherin, were identified as direct targets of all five members of the miR-200 family. This evidence concerns the gene ZEB1 and neoplasm.