Mutations or CNVs of METTL14, METTL3, VIRMA, RBM15, ZC3H13, WTAP, YTHDC1, YTHDC2, YTHDF1, YTHDF2, HNRNPC, FTO, and ALKBH5 as a subgroup were significantly correlated with lower albumin (P = 0.038, Table S1), and poorer tumor stage in HCC (P < 0.0043, Table S1). The gene discussed is VIRMA; the disease is hepatocellular carcinoma.