A variety of isoprenoids and their derivatives such as farnesol, sesquiterpene, γ-tocotrienol, cyclic monoterpenes, d-limonene, perillyl alcohol and β-ionone decreases HMGCR content and consequently, induces cell cycle arrest and apoptosis in tumor cells (Elson et al., 1999 ▶; Mo et al., 2012 ▶; Parker et al., 1993 ▶). Here, HMGCR is linked to neoplasm.