HMGCR and neoplasm: Beyond statins, isoprenoids are mevalonate-derived secondary metabolites of plants that have been introduced not only as the suppressor of HMGCR activity (Elson et al., 1999 ▶; Elson and Qureshi, 1995 ▶; Parker et al., 1993 ▶), but also as chemicals that downregulate the tumor HMGCR activity.