In comparison to poorly differentiated case, advanced TNM stage (III or IV), lymph node metastasis, region invasion, and biopsy only, positive rates of DSG1 and DSG2 expression were both upregulated in cases with the well differentiated type, TNM I + II stage, no lymph node metastasis, radical surgery, and no invasion (P < 0.01) (Table 1). The gene discussed is DSG2; the disease is metastatic malignant neoplasm in the lymph nodes.