After a thorough search and screening, we selected 28 articles; out of these, 12 articles focused on the relationship between pancreatic cancer and major depression, 12 articles focused on the association of IL-6 and inflammation with the development and progression of pancreatic cancer, and 6 articles focused on the association between IL-6 and major depression; some of them were included in more than one subcategory. Here, IL6 is linked to major depressive disorder.